Anti-GAPDH Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:5000.
交叉反應(yīng) Human Mouse Rat

產(chǎn)品型號(hào)：K106389P

更新時(shí)間：2022-08-15

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抗體

標(biāo)簽抗體血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗內(nèi)參抗體膠體金標(biāo)記二抗生物素化二抗 RBITC熒光標(biāo)記抗體二抗 FITC熒光標(biāo)記抗體二抗免疫血清二抗純化抗體二抗 HRP標(biāo)記二抗免疫球蛋白抗原IgG二抗

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產(chǎn)品介紹

Anti-GAPDH Polyclonal Antibody

英文名稱	Anti-GAPDH Polyclonal Antibody
宿主	Rabbit
別名	GAPD;CDABP0047;OK/SW-cl.12;G3PD;HEL-S-162eP
應(yīng)用	WB
稀釋比例	WB 1:5000.
蛋白分子量	36kDa
Gene ID	2597
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	Recombinant protein of human GAPDH
性狀	液體
Public Immunogen Range	Recombinant protein of human GAPDH
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	P04406
克隆類型	Polyclonal Antibody
背景資料	Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively expressed in almost all tissues at high levels. There are however some physiological factors such as hypoxia and diabetes that increase GAPDH expression in certain cell types. GAPDH molecule is composed of four 36kDa subunits.

多克隆抗體

抗原通常是由多個(gè)抗原決定簇組成的，由一種抗原決定簇刺激機(jī)體，由一個(gè)B淋巴細(xì)胞接受該抗原所產(chǎn)生的抗體稱之為單克隆抗體（Monclone antibody）。由多種抗原決定簇刺激機(jī)體，相應(yīng)地就產(chǎn)生各種各樣的單克隆抗體，這些單克隆抗體混雜在一起就是多克隆抗體（Polyclonal antibody），機(jī)體內(nèi)所產(chǎn)生的抗體就是多克隆抗體。

由于多克隆抗體通常包含抗某一抗原的不同表位的抗體，所以，在深固定的樣本中也會(huì)很好地發(fā)揮效應(yīng)，在石蠟包埋組織切片的染色中，多克隆抗體選用。根據(jù)實(shí)驗(yàn)的不同需要，多克隆抗體應(yīng)用于相應(yīng)抗原的標(biāo)記。此外，在農(nóng)業(yè)生產(chǎn)中，多克隆抗體被用于農(nóng)藥殘留現(xiàn)場(chǎng)監(jiān)測(cè)；在臨床應(yīng)用中，多克隆抗體主要用于病原物的檢測(cè)、疾病的診斷及治療，如作為蛋白類免疫抑制劑用于移植反應(yīng)和自身免疫病的治療。

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